氨基酸螯合鐵(Iron amino acid chelate)對動物吸收的影響

大量研究表明動物機體對甘氨酸螯合鐵有更好的生物利用率，而甘氨酸螯合鐵較好的生物學效價可能與其在動物機體內的吸收機制有關。動物機體吸收外源鐵主要發生在十二指腸和空腸上段，并需要相關膜轉運蛋白的協助。二價金屬離子轉運蛋白 (Divalent Metal Transporter 1，DMT1) 可將腸道內包括Fe²⁺ 在內的二價金屬離子轉運到細胞內，其主要分布在動物十二指腸絨毛刷狀緣及隱窩等處，其表達變化主要由感知體內鐵儲存的反饋機制來調控；基底膜鐵轉運蛋白 (Ferroportin 1，Fpn1) 主要負責將細胞內的鐵轉運到血液中。植酸和纖維素等抗營養因子能夠與腸道中的亞鐵離子反應，形成不溶性復合物，從而影響鐵離子在腸道內的吸收；氨基酸螯合鐵中的鐵元素因為和氨基酸配體的螯合作用，可以避免植酸和纖維素等因素的影響，從而獲得更好地吸收效果；在 Caco-2 細胞模型上，抗壞血酸鐵和氨基酸螯合鐵具有相似的鐵吸收機制，均是以鐵離子的形式通過細胞中的 DMT1 吸收的。

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賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、牛磺酸硒Selenium Taurate、抗壞血酸錳Manganese Ascorbate、抗壞血酸亞鐵Ferrous Ascorbate

Effects of Iron amino acid chelate on animal absorption

Many studies have shown that animals have better bioavailability of iron glycine chelate, and the better biological titer of iron glycine chelate may be related to the absorption mechanism in animals. The absorption of exogenous iron mainly occurs in the duodenum and upper jejunum, and requires the assistance of related membrane transporters. Divalent Metal Transporter 1 (DMT1) can transport intestinal divalent metal ions, including Fe²⁺, into cells, mainly at brush margins and crypts of duodenal villi. The change of its expression is mainly regulated by the feedback mechanism of sensing iron storage in vivo. Ferroportin 1 (Fpn1) is responsible for transporting iron from cells into the blood. Phytic acid, cellulose and other anti-nutrient factors can react with ferrous ions in the intestine to form insoluble complexes, thus affecting the absorption of iron ions in the intestine. The iron element in amino acid chelate iron can avoid the influence of phytic acid and cellulose because of chelating with amino acid ligand, so as to obtain better absorption effect. In the Caco-2 cell model, iron ascorbate and iron amino acid chelate have similar iron absorption mechanisms, both of which are absorbed by DMT1 in the cell in the form of iron ion.

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Magnesium Lysinate Glycinate, Magnesium Glycinate Glutamine, Magnesium Citrate Malate, Strontium citrate Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Selenium Taurate, Manganese ascorbate Ferrous Ascorbate Ascorbate.