銅穩(wěn)態(tài)：生命活動(dòng)的關(guān)鍵調(diào)控者及其在疾病中的潛在角色（檸檬酸銅Copper Citrate、氨基酸螯合銅Copper Amino Acid Chelate）。

銅穩(wěn)態(tài)是近2年熱點(diǎn)話題之一，最近研究發(fā)現(xiàn)依賴銅穩(wěn)態(tài)機(jī)制的銅死亡在腫瘤、肝病、神經(jīng)功能疾病中發(fā)揮巨大作用。銅是人體必需微量元素之一，全身含量約為 100mg。銅在生命活動(dòng)中發(fā)揮著關(guān)鍵催化輔因子的作用，包括線粒體呼吸、抗氧化和蛋白質(zhì)合成等。值得注意的是，細(xì)胞內(nèi)銅濃度一般保持在相對穩(wěn)定的范圍內(nèi)，濃度上升會(huì)產(chǎn)生細(xì)胞毒性，甚至導(dǎo)致細(xì)胞死亡。銅的吸收、分布和清除受到嚴(yán)格調(diào)節(jié)，因此銅穩(wěn)態(tài)平衡的維持對生命活動(dòng)具有重要意義，而銅穩(wěn)態(tài)涉及銅代謝和銅死亡兩部分。維持銅穩(wěn)態(tài)對機(jī)體具有重要作用，銅失衡會(huì)導(dǎo)致氧化應(yīng)激、氧化應(yīng)激、自噬、蛋白失活、線粒體功能損傷等一系列反應(yīng)，甚至誘發(fā)銅死亡，導(dǎo)致細(xì)胞發(fā)生程序性死亡。

銅穩(wěn)態(tài):生命活動(dòng)的關(guān)鍵調(diào)控者及其在疾病中的潛在角色（檸檬酸銅Copper Citrate、氨基酸螯合銅Copper Amino Acid Chelate）。

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Copper homeostasis: a key regulator of life activities and its potential role in diseases (copper citrate, copper amino acid chelate).

Copper homeostasis has been one of the hot topics in the past two years. Recent studies have found that copper death, which depends on the copper homeostasis mechanism, plays a huge role in tumors, liver diseases, and neurological diseases. Copper is one of the essential trace elements for the human body, with a total body content of about 100 mg. Copper plays a key catalytic cofactor role in life activities, including mitochondrial respiration, anti-oxidation, and protein synthesis. It is worth noting that the intracellular copper concentration generally remains within a relatively stable range. An increase in concentration will produce cytotoxicity and even lead to cell death. The absorption, distribution, and clearance of copper are strictly regulated, so the maintenance of copper homeostasis is of great significance to life activities, and copper homeostasis involves copper metabolism and copper death. Maintaining copper homeostasis plays an important role in the body. Copper imbalance can lead to a series of reactions such as oxidative stress, oxidative stress, autophagy, protein inactivation, and mitochondrial function damage, and even induce copper death, leading to programmed cell death.

Copper homeostasis: a key regulator of life activities and its potential role in disease (Copper Citrate, Copper Amino Acid Chelate).

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