錳離子（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）對肝癌細胞增殖及凋亡的影響

一般認為微量元素含量的失衡可導致DNA的不穩定，從而構成了癌癥發生的前提條件。有研究發現，在錳（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）缺失的小鼠體內腫瘤細胞的生長和腫瘤肺轉移顯著增強，腫瘤浸潤的CD8+T細胞明顯減少，表明錳元素（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）不足可能導致腫瘤加速增長，其在抑制腫瘤的發生發展中可能發揮至關重要作用，研究發現，在胃癌細胞AGS、BGC-823中添加錳離子（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate），發現可增強牛乳鐵蛋白水解物的抗癌效果，使其具有更強的生長抑制作用，并促進細胞凋亡，同時導致更多的細胞被阻滯在G0/G1期。還有研究表明，錳（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）可以通過激活細胞caspase-3途徑和caspase-12途徑誘導宮頸癌細胞HeLa和小鼠胚胎成纖維細胞NIH3T3細胞凋亡；在肝癌Huh7和HepG2.2.15細胞中也觀察到錳離子（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）在多個濃度下均能抑制肝癌細胞增殖活力及克隆形成，并促進細胞凋亡，而且隨著錳離子（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）溶液濃度的增大，細胞增殖活力及克隆形成能力隨之降低，而凋亡率隨之增大，說明錳離子（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）對肝癌細胞的抑制作用具有劑量依賴性，且腫瘤微環境中低濃度的錳可能更有利于肝癌的發生發展。

錳離子（甘氨酸錳Manganese Glycinate、抗壞血酸錳Manganese Ascorbate）對肝癌細胞增殖及凋亡的影響

公司官網：www.wilincare.net歡迎選購！

抗壞血酸錳Manganese Ascorbate、抗壞血酸亞鐵Ferrous Ascorbate、賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、牛磺酸硒Selenium Taurate.

Effect of manganese ions (Manganese glycinate, Manganese ascorbate) on the proliferation and apoptosis of hepatocellular carcinoma cells

It is generally believed that an imbalance in trace element content can lead to DNA instability, which constitutes a prerequisite for the occurrence of cancer. It has been found that the growth of tumor cells and tumor lung metastasis in mice with manganese (manganese glycinate, manganese ascorbate) deletion are significantly enhanced, and the CD8+ T cells infiltrated by tumors are significantly reduced, indicating that insufficient manganese (manganese glycinate, manganese ascorbate) may lead to accelerated tumor growth. It may play a crucial role in inhibiting the occurrence and development of tumors, and studies have found that adding manganese ions (Manganese glycinate, Manganese ascorbate) to gastric cancer cells AGS and BGC-823 has been found to enhance the anti-cancer effect of bovine lactoferrin hydrolysate, making it have a stronger growth inhibitory effect, and promote apoptosis, while causing more cells to be arrested in the G0/G1 phase. Other studies have shown that manganese (Manganese glycinate, Manganese ascorbate) can induce apoptosis of cervical cancer cells HeLa and mouse embryonic fibroblasts NIH3T3 cells by activating the cellular caspase-3 pathway and caspase-12 pathway. In HCC Huh7 and HepG2.2.15 cells, manganese ions (Manganese glycinate, Manganese ascorbate) were also observed to inhibit the proliferation and clonal formation of HCC cells and promote apoptosis at multiple concentrations Ascorbate) solution decreased the cell proliferation activity and clone formation ability, and the apoptosis rate increased, indicating that the inhibitory effect of manganese ions (Manganese glycinate, manganese ascorbate) on hepatocellular carcinoma cells was dose-dependent, and low concentrations of manganese in the tumor microenvironment may be more conducive to the occurrence and development of hepatocellular carcinoma.

Effect of manganese ions (Manganese glycinate, Manganese ascorbate) on the proliferation and apoptosis of hepatocellular carcinoma cells

Company official website: www.wilincare.net Welcome to buy!

Manganese Ascorbate, Ferrous Ascorbate, Magnesium Lysinate Glycinate, Magnesium Glycinate Glutamine, Magnesium Citrate Malate, Strontium Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Selenium Taurate.